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Molecules and Mental Illness (Scientific American Library Paperback), by Samuel H. Barondes
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This text explains the biological foundations of mental illness, and the impact of findings on the pharmacological treatment of those illnesses. The first half of the book discusses the molecular and genetic causes of mental illnesses; while the second half looks at psychiatric disorders through the eyes of sufferers of manic depression, schizophrenia, phobias and sufferers of compulsive disorders. The book also includes coverage of late-1990s' research and treatment.
- Sales Rank: #3100815 in Books
- Brand: Brand: W H Freeman n Co
- Published on: 1999-06
- Original language: English
- Number of items: 1
- Dimensions: 9.25" h x 8.75" w x .50" l, 1.21 pounds
- Binding: Paperback
- 215 pages
- Used Book in Good Condition
Review
"Dr. Barondes does a remarkable job in trying to bring together, in a single volume, data concerning molecular biology, molecular genetics, and psychiatric illness." -- Charles B. Nemeroff, M.D., Ph.D., Professor and Chairman, Department of Psychiatry and Behavioral Science, Emory University School of Medicine
"This book is perhaps best described as a brief guided tour, for the nonspecialist, through biological psychiatry from a molecular/cellular perspective. Its strength is its special combination of accuracy and readability: the author is a highly informed expert, and the production staff is experienced in popular scientific publishing." -- American Journal of Psychiatry
"This volume is written in a lively, lucid style that makes complex ideas eminently accessible. . . . It is an important contribution that will interest all thoughtful readers." -- Nature
About the Author
Samuel H. Barondes, M.D., is the Jeanne and Sanford Robertson Professor and Director of the Center for Neurobiology and Psychiatry at the University of California, San Francisco. A member of the Institute of Medicine of the National Academy of Sciences, he also serves as President of the McKnight Endowment Fund for Neuroscience and recently chaired the Workgroup on Genetics of the National Institute of Mental Health. Barondes is also the author of Mood Genes: Hunting for Origins of Mania and Depression (W. H. Freeman, 1998). He lives in San Francisco.
Most helpful customer reviews
7 of 7 people found the following review helpful.
Overview and Future of Modern Psychiatry in 215 pages
By Nancy Moran
I asked a doctor I respected to recommend a book which was a short synopsis of the biochemical basis of Psychiatry and he said, "Amazon - up on Amazon". He was right.
The book contained some "extras" I hadn't anticipated. It is written by a Psychiatry Department Chairman (Samuel H. Barondes) and was definitely intended to cover the highlights and future of the field.
"Molecules and Mental Illness" is a phenomenal book but it should better be titled "Overview and Future of Modern Psychiatry for Those Having a Background in Science".
It is unfortunate that young doctors these days have no familiarity with the magazine, "Scientific American" for this would be a fine read for senior medical students considering Psychiatry as a specialty, for residents in Psychiatry to be reminded of the scientific, cellular and molecular basis of what they are practicing, or for more senior doctors needing a refresher course or needing an overview of the field.
Starting with an overview of the history of biological psychiatry then gross and molecular genetics, the next third of the book has to do with macro- and micro- biology with great emphasis on neuronal membrane and different receptors, eventually covering known interactions of drugs with the membrane and across a synapse.
The next third of the book delves into the major mental illnesses (schizophrenia, mania and depression, obsessive-compulsive disorder) along with their diagnostic criteria, genetics, and drug therapies (there is scant mention of electroconvulsive therapy and psychotherapy).
This book is loaded with color reproductions of paintings, of chromosomes, of neurons (cross-section intracellular, synaptically, as conductors of electrical signals), of the biochemistry of the nervous system (i.e., membrane dynamics), charts, graphs, etc., etc., etc. It is replete with schematics of relevant molecules (legal and illegal).
The Table of Contents is short, sweet and to the point.
The book itself is concise and readable but comprehensive.
Curiously, the book ends with a "Recapitulation (In Verse)", four subsections: Freud, Drugs, Genes, Stories.
"Since understanding molecules
That drive us to insanity
Provides a giant window on
The nature of humanity."
I recommend it highly to science-oriented persons and to physicians. At its price, it is a "bargain" book.
This book would be ideal for Amazon's "Look Inside" feature.
1 of 3 people found the following review helpful.
About the Book
By Promilla C. Gupta
About the Book
In the past few decades we have learned a great deal about proteins and nucleic acids, the molecular building blocks of all biological systems. This knowledge is being applied in many branches of medicine. The goal of this book is to show its impact on our view of mental illness and its treatment.
Until recently, few people have been thinking about the connections between molecules and mental illness, because to do this requires familiarity with two very different intellectual and professional traditions. Myopportunity to combine them came during my postdoctoral training at the National Institutes of Health (NIH) between 1960 and 1963. When I arrived at NIH, I had completed medical school and was thinking of embarking on a career in psychiatry. But I also wanted to learn more about fundamental biology by working in a laboratory. At NIH I met Gordon Tomkins, who was deeply committed to relating basic science to medicine and had founded a department to achieve this goal. Gordon was bursting with knowledge and enthusiasm about the infant field of molecular biology and was convinced that it would ultimately explain almost everything (which, to me, meant even psychiatry).
To provide a taste of molecular biology, Gordon arranged for me to become the second postdoctoral fellow in the then tiny laboratory of Mar-shall Nirenberg. I began there immediately before Marshall`s discovery that a synthetic nucleic acid, called poly U, could act as an artificial genetic message. Within months I became an industrious student of poly U, while Marshall went on to work with other synthetic nucleic acids, ultimately deciphering the genetic code by which nucleic acid sequences are translated into the language of proteins. It was obvious to me, and to everyone else, that Marshall`s work was monumental; and within a few years it was honored with a Nobel prize. The experience was an extraordinarily exciting introduction to the laboratory, and supported Gordon`s belief that, if you study things at the molecular level, anything is possible. I was hooked.
After a year in Gordon`s laboratory in which I began to use molecular techniques to study the mechanism for storing memories in the brain, I went on to psychiatric training and have worked in both psychiatry and basic biological sciences ever since. Although the integration of these fields has progressed more slowly than I would have liked, the pace is picking up. This book is designed to provide enough essential information about biology and psychiatry for readers unfamiliar with both fields to appreciate how they are coming together.
In writing this book I have been greatly aided by the advice of many colleagues and friends and have enjoyed the benefit of working with an extraordinary group of professionals at Scientific American Library. Two people I wish to single out for special thanks are my editor, Sonia Deviatory, and my assistant Anne Poirier, who each made invaluable contributions. My daughters Elizabeth and Jessica, both more comfortable with words than with molecules, were often my target audience. "Recapitulation (in Verse)" is especially for them. I hope you like it too.
14 of 14 people found the following review helpful.
Excellent primer on the chemistry of the brain.
By A Customer
Dr. Barondes makes an incredibly complex subject easy to understand. He packs a great deal of information into a few, well illustrated pages. The book starts in the history of neurology, then explains the structure of neurons and goes on to describe the different brain chemicals and how they work on a molecular level.
Because of its clarity, this book would make an excellent textbook for teaching neurochemistry and its interactions with the mind.
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